5-Chloro-2-fluoronicotinic acid

5-Chloro-2-fluoronicotinic acid - Names and Identifiers

Name	5-chloro-2-fluoro-pyridine-3-carboxylic acid
Synonyms	LogP 2-FLUORO-5-CHLORONICOTINIC ACID 5-Chloro-2-fluoronicotinic acid 5-CHLORO-2-FLUORONICOTINIC ACID 2-Fluoro-5-chloropyridine-3-carboxylic acid 5-chloro-2-fluoropyridine-3-carboxylic acid 5-Chloro-2-fluoro-3-pyridinecarboxylic acid 5-chloro-2-fluoro-pyridine-3-carboxylic acid 3-Pyridinecarboxylic acid, 5-chloro-2-fluoro-
CAS	884494-57-9
InChI	InChI=1/C6H3ClFNO2/c7-3-1-4(6(10)11)5(8)9-2-3/h1-2H,(H,10,11)

5-Chloro-2-fluoronicotinic acid - Physico-chemical Properties

Molecular Formula	C6H3ClFNO2
Molar Mass	175.54
Density	1.576
Boling Point	308.2±37.0 °C(Predicted)
Flash Point	140.183°C
Vapor Presure	0mmHg at 25°C
pKa	2.17±0.10(Predicted)
Storage Condition	2-8℃
Refractive Index	1.563

5-Chloro-2-fluoronicotinic acid - Risk and Safety

Hazard Class

IRRITANT

5-Chloro-2-fluoronicotinic acid - Introduction

Acid is an organic compound with the chemical formula C6H3ClFNO2. The following is an introduction to its nature, use, formulation and safety information:

Nature:
-Appearance: Colorless or yellowish solid
-melting point: 132-135 ℃
-Boiling point: 337.2 ℃
-Density: 1.61g/cm³
-Soluble: Soluble in ethanol, dichloromethane and dimethyl sulfoxide

Use:
-must acid is an important intermediate in organic synthesis.
-It is often used in the synthesis of drugs and pesticides, such as etheric acid (Ethambutol) for the synthesis of anti-tuberculosis drugs.

Preparation Method:
The preparation of acid can be carried out by the following steps:
-2-amino-5-chloronicotinic acid (2-Amino-5-chloropyridine) is reacted with hydrogen fluoride to give 2-fluoro-5-aminonicotinic acid (2-Fluoro-5-aminopyridine).
-Then react 2-fluoro-5-aminonicotinic acid with chloroformic acid to obtain acid.

Safety Information:
-must acid generally have low toxicity under normal use conditions.
-During handling and storage, care should be taken to avoid inhalation, ingestion or contact with skin and eyes.
-Use appropriate protective equipment, such as gloves and goggles, when handling the compound.
-In case of accidental contact, flush the affected area immediately with plenty of water and seek medical help.

Last Update：2024-04-09 15:18:00